Latest Research
We work with advisors and allied professionals to participate in the latest research in symptomatic hypermobility and neurodivergence.
Nutritional Considerations for Hypermobile Ehlers-Danlos Syndrome
Cheryl Iny Harris, Dacre R.T. Knight, Lisa A. Mejia, Laurie Bilyeu
While the hallmarks of hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum
disorders (HSD) are pain, joint instability, and injuries to soft tissues, most patients with hEDS and
HSD have a myriad of manifestations within the gastrointestinal tract that affect dietary tolerance
and quality of life.
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Gastrointestinal Manifestations of hEDS/HSD
Laura Brockway, Specialist Nurse
The Ehlers-Danlos syndromes (EDS) is the name given to a group of non-inflammatory hereditary conditions, which are all disorders of the connective tissue. Connective tissue is a supporting structure in our body and is made up of a number of proteins including collagen, which is the protein most often thought to be involved in EDS. Collagen is abundant in skin, muscles and ligaments where it gives these structures strength and support. Changes in the collagen proteins can mean that these structures are more ‘stretchy’ in EDS.
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Sleep disorders in patients with postural tachycardia syndrome: A review of the literature and guide for clinicians
Mitchell G. Miglisa, Fiona Barwick
Fatigue is common in POTS, and patients often report unrefreshing sleep. These symptoms are directly correlated with a reduced quality of life, however the treatment of sleep disorders in this population remains a challenge. This article will review the current literature on the prevalence of sleep disorders in POTS, their association with the underlying pathophysiology of POTS, and current treatment paradigms.
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Correlation between benign joint hypermobility syndrome and headache in children and adolescents
Mohsen Jari & Sogol Alesaeidi
Benign Joint Hypermobility Syndrome (BJHS) is a most common hereditary connective tissue disorders in children and adolescents. This study aimed to investigate the prevalence and subtypes of headache in children with BJHS.
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Joint Hypermobility Links Neurodivergence to Dysautonomia and Pain
Cheryl Iny Harris, Dacre R.T. Knight, Lisa A. Mejia, Laurie Bilyeu
While the hallmarks of hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum
disorders (HSD) are pain, joint instability, and injuries to soft tissues, most patients with hEDS and
HSD have a myriad of manifestations within the gastrointestinal tract that affect dietary tolerance
and quality of life. These include irritable bowel syndrome, functional dyspepsia, gastroparesis,
constipation, and celiac disease.
Read more.
Is joint hypermobility linked to self reported non-recovery from COVID-19? COVID Symptom Study Biobank 2024
Jessica A Eccles, Dorina Cadar, Lisa Quadt, Alan J Hakim, Nicholas Gall; Covid Symptom Survey Biobank Consortium, Vicky Bowyer, Nathan Cheetham, Claire J Steves, Hugo D Critchle, Kevin A Davies
This study sought to explore whether generalised joint hypermobility (GJH, a common marker of variant connective tissue) was a risk factor for self-reported non-recovery from COVID-19 infection.
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A model linking emotional dysregulation in neurodivergent people to the proprioceptive impact of joint hypermobility (2024)
Jessica A. Eccles, Lisa Quadt, Sarah N. Garfinkel and Hugo D. Critchley
Emotional feelings are putatively ascribed to central representation of bodily states in the context of expectation and uncertainty in both internal state and external world. Neurodivergent people are more likely to experience co-occurring mental health challenges, although mechanistic insights underpinning this association are scarce. We therefore undertook a study to test whether imprecise processing of proprioceptive error signals may underlie the connection between neurodivergence and emotional dysregulation.
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Do people with M.E./CFS and joint hypermobility represent a disease subgroup? An analysis using registry data.
Allison Ramiller, Sadie Whittaker, Leslie E. Phillips
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic, multifaceted disease that affects millions globally. Despite its significant impact, the disease's etiology remains poorly understood, and symptom heterogeneity poses challenges for diagnosis and treatment. Joint hypermobility, commonly seen in hypermobile Ehlers-Danlos Syndrome (hEDS), has been observed in ME/CFS patients but its prevalence and clinical significance within this population are not well-characterized.
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Misophonia reactions in the general population are correlated with strong emotional reactions to other everyday sensory–emotional experiences (2024)
Solena D. Mednicoff, Sivan Barashy, David J. Vollweiler, Stephen D. Benning, Joel S. Snyder and Erin E. Hannon
Misophonic experiences are common in the general population, and they may shed light on everyday emotional reactions to multi-modal stimuli. We performed an online study of a non-clinical sample to understand the extent to which adults who have misophonic reactions are generally reactive to a range of audio-visual emotion-inducing stimuli.
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Variant connective tissue (joint hypermobility) and its relevance to depression and anxiety in adolescents: a cohort-based case–control study.ā
Jessica A Eccles, Lisa Quadt, Hannah McCarthy, Kevin A Davies, Rod Bond, Anthony S David, Neil A Harrison, Hugo D Critchley
To test whether variant connective tissue structure, as indicated by the presence of joint hypermobility, poses a developmental risk for mood disorders in adolescence.
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Tourette syndrome associated with attention deficit hyperactivity disorder: The impact of tics and psychopharmacological treatment options
Jenny L L Csecs, Valeria Iodice, Charlotte L Rae, Alice Brooke, Rebecca Simmons, Lisa Quadt, Georgia K Savage, Nicholas G Dowell, Fenella Prowse, Kristy Themelis, Christopher J Mathias, Hugo D Critchley, Jessica A Eccles
Autism, attention deficit hyperactivity disorder (ADHD), and tic disorder (Tourette syndrome; TS) are neurodevelopmental conditions that frequently co-occur and impact psychological, social, and emotional processes. Increased likelihood of chronic physical symptoms, including fatigue and pain, are also recognised.
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Co-Occurring Physical Health Challenges in Neurodivergent Children and Young People: A Topical Review and Recommendation
Bethany Donagh, David Moore & Jane Green
Neurodivergence has been established as associated with a significant number of co-occurring physical conditions, particularly for autistic individuals who are at risk for increased pain, hypermobility (including Ehlers-Danlos Syndrome) and gastrointestinal problems. However, data, so far, has been focused on adults and generally limited to discussions of condition prevalence alone.
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